Probe: GLP her-2/csp17 (17q11.2-q12/17p11.1-q11.1)
Sample: Paraffin sample (breast cancer, stomach cancer etc.)
Clinical Significance:
1. Screening of Herceptin, Tykerb, T-DM1 and other targeted drugs, breast cancer HER-2 overexpression, advanced gastric cancer, patients with gastro-esophageal junction adenocarcinoma may choose targeted drugs therapy.
2. Evaluate the prognosis of breast cancer, the prognosis of patients with HER-2 gene amplification is poor, the disease-free survival period and the total survival period are significantly shortened.
3. Guidance for breast cancer endocrine therapy, HER-2 gene amplification in patients under endocrine therapy is not sensitive.
4. Guide breast cancer adjuvant chemotherapy drug selection, HER-2 gene amplification in patients with high degree of malignancy, decreased responsiveness to CMF chemotherapy regimen, paclitaxel and anthracycline-based high-intensity chemotherapy drugs should be recommended.
HER-2 Gene Amplification FISH Probe Kit
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