Human CYP2C19 Gene Polymorphism Detection Kit

PCR-Fluorescence Probe - Clopidogrel Medication Guidancea)


a) Clinical UseClopidogrel (Plavix) is an oral antiplatelet drug that can be used to prevent and treat myocardial infarction, ischemic cerebral thrombosis, occlusive vasculitis, atherosclerosis and thromboembolism caused complications. However, Clopidogrel must be biologically converted in the body into an active product to inhibit platelets’ aggregation. This biotransformation process requires cytochrome P450 encoded by the CYP2C19 gene in the liver metabolism, and the active product can selectively and irreversibly block the diphosphate adenosine-dependent platelet aggregation. The CYP2C19 gene loci alleles 681, 636 and -806 Clopidogrel metabolic enzymes are closely related to its anticoagulant effect, and Clopidogrel dose